Humanized mouse models to study human diseases
MA Brehm, LD Shultz, DL Greiner - Current Opinion in …, 2010 - journals.lww.com
MA Brehm, LD Shultz, DL Greiner
Current Opinion in Endocrinology, Diabetes and Obesity, 2010•journals.lww.comImmunodeficient mice bearing an IL2rγ null mutated gene can be engrafted with functional
human cells and tissues, including human immune systems, following engraftment with
human hematolymphoid cells. These mice are now used as in-vivo models to study human
hematopoiesis, immunity, regeneration, stem cell function, cancer, and human-specific
infectious agents without putting patients at risk.
human cells and tissues, including human immune systems, following engraftment with
human hematolymphoid cells. These mice are now used as in-vivo models to study human
hematopoiesis, immunity, regeneration, stem cell function, cancer, and human-specific
infectious agents without putting patients at risk.
Summary
Immunodeficient mice bearing an IL2rγ null mutated gene can be engrafted with functional human cells and tissues, including human immune systems, following engraftment with human hematolymphoid cells. These mice are now used as in-vivo models to study human hematopoiesis, immunity, regeneration, stem cell function, cancer, and human-specific infectious agents without putting patients at risk.
Lippincott Williams & Wilkins