The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic …

GM McKhann, DS Knopman, H Chertkow… - Alzheimer's & …, 2011 - Elsevier
The National Institute on Aging and the Alzheimer's Association charged a workgroup with
the task of revising the 1984 criteria for Alzheimer's disease (AD) dementia. The workgroup
sought to ensure that the revised criteria would be flexible enough to be used by both
general healthcare providers without access to neuropsychological testing, advanced
imaging, and cerebrospinal fluid measures, and specialized investigators involved in
research or in clinical trial studies who would have these tools available. We present criteria …

Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on …

RA Sperling, PS Aisen, LA Beckett, DA Bennett… - Alzheimer's & …, 2011 - Elsevier
The pathophysiological process of Alzheimer's disease (AD) is thought to begin many years
before the diagnosis of AD dementia. This long “preclinical” phase of AD would provide a
critical opportunity for therapeutic intervention; however, we need to further elucidate the link
between the pathological cascade of AD and the emergence of clinical symptoms. The
National Institute on Aging and the Alzheimer's Association convened an international
workgroup to review the biomarker, epidemiological, and neuropsychological evidence, and …