The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8+ T cells into innate-like effector cells with antitumor activity
HC Wong, EK Jeng, PR Rhode - Oncoimmunology, 2013 - Taylor & Francis
HC Wong, EK Jeng, PR Rhode
Oncoimmunology, 2013•Taylor & FrancisALT-803, an interleukin-15-based superagonist, induces memory CD8+ T cells to proliferate,
upregulate receptors involved in innate immunity, secrete interferon γ and acquire the ability
to kill malignant cells in the absence of antigenic stimulation. Thus, ALT-803 can promote
the expansion and activation of memory CD8+ T cells while converting them into innate
immune effector cells that exhibit robust antineoplastic activity.
upregulate receptors involved in innate immunity, secrete interferon γ and acquire the ability
to kill malignant cells in the absence of antigenic stimulation. Thus, ALT-803 can promote
the expansion and activation of memory CD8+ T cells while converting them into innate
immune effector cells that exhibit robust antineoplastic activity.
ALT-803, an interleukin-15-based superagonist, induces memory CD8+ T cells to proliferate, upregulate receptors involved in innate immunity, secrete interferon γ and acquire the ability to kill malignant cells in the absence of antigenic stimulation. Thus, ALT-803 can promote the expansion and activation of memory CD8+ T cells while converting them into innate immune effector cells that exhibit robust antineoplastic activity.
Taylor & Francis Online