[PDF][PDF] More on shift of HIV tropism in stem-cell transplantation with CCR5 delta32/delta32 mutation

A Abbate, KJ Gold, KL Goldman JWEBD… - N Engl J …, 2014 - researchgate.net
To the Editor: In 2009, my colleagues and I reported the successful transplantation of stem
cells with a 32-bp deletion in the chemokine (CC motif) receptor 5 (CCR5) allele (CCR5
delta32/delta32) in a patient who was infected with the human immunodeficiency virus type
1 (HIV-1). This finding has led to further research to find a cure for HIV-1 infection. 1
Repetition of this unique approach to provide a proof of principle was awaited. Kordelas et
al.(Aug. 28 issue) 2 describe another patient in whom the same approach failed.

[HTML][HTML] Shift of HIV Tropism in Stem-Cell Transplantation with CCR5 Delta32 Mutation

L Kordelas, J Verheyen, S Esser - New England Journal of …, 2014 - Mass Medical Soc
To the Editor: Infection with the human immunodeficiency virus (HIV) requires entry into
target cells by binding of the viral envelope to the CD4 receptor and to either the chemokine
(CC motif) receptor 5 (CCR5) or the chemokine (CXC motif) receptor 4 (CXCR4).
Homozygosity for a 32-bp deletion in the CCR5 allele (CCR5 delta32) prevents cellular
entry of CCR5-tropic (R5-tropic) HIV type 1 (HIV-1) strains. In 2009, there was a report1
about an HIV-1–infected patient with acute myeloid leukemia in whom the viral load …