Plasma viremia and cellular HIV-1 DNA persist despite autologous hematopoietic stem cell transplantation for HIV-related lymphoma
AR Cillo, A Krishnan, RT Mitsuyasu… - JAIDS Journal of …, 2013 - journals.lww.com
JAIDS Journal of Acquired Immune Deficiency Syndromes, 2013•journals.lww.com
A cure of HIV-1 has been achieved in one individual through allogeneic stem cell
transplantation with a CCR5 [INCREMENT] 32 homozygous donor. Whether myeloablation
and autologous stem cell transplantation for lymphoma in patients on suppressive
antiretroviral therapy can eliminate HIV-1 reservoirs is unknown. Low-level plasma viremia
and total HIV-1 DNA and 2-LTR circles in blood mononuclear cells were quantified after
autologous transplantation in 10 patients on suppressive antiretroviral therapy using …
transplantation with a CCR5 [INCREMENT] 32 homozygous donor. Whether myeloablation
and autologous stem cell transplantation for lymphoma in patients on suppressive
antiretroviral therapy can eliminate HIV-1 reservoirs is unknown. Low-level plasma viremia
and total HIV-1 DNA and 2-LTR circles in blood mononuclear cells were quantified after
autologous transplantation in 10 patients on suppressive antiretroviral therapy using …
Abstract
A cure of HIV-1 has been achieved in one individual through allogeneic stem cell transplantation with a CCR5 [INCREMENT] 32 homozygous donor. Whether myeloablation and autologous stem cell transplantation for lymphoma in patients on suppressive antiretroviral therapy can eliminate HIV-1 reservoirs is unknown. Low-level plasma viremia and total HIV-1 DNA and 2-LTR circles in blood mononuclear cells were quantified after autologous transplantation in 10 patients on suppressive antiretroviral therapy using quantitative polymerase chain reaction assays capable of single-copy nucleic acid detection. Plasma viremia was detectable in 9 patients, whereas HIV-1 DNA was detectable in all 10 patients, indicating that HIV-1 had not been eliminated.
Lippincott Williams & Wilkins