Clinical factors associated with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections
The Journal of pediatrics, 2012•Elsevier
OBJECTIVE: To explore associated clinical factors in children with pediatric autoimmune
neuropsychiatric disorders associated with streptococcal infections (PANDAS). STUDY
DESIGN: Children with tics, obsessive-compulsive disorder, or both (n= 109) were examined
with personal and family history, diagnostic interview, physical examination, medical record
review, and measurement of baseline levels of streptococcal antibodies. RESULTS:
Significant group differences were found on several variables, such that children in whom …
neuropsychiatric disorders associated with streptococcal infections (PANDAS). STUDY
DESIGN: Children with tics, obsessive-compulsive disorder, or both (n= 109) were examined
with personal and family history, diagnostic interview, physical examination, medical record
review, and measurement of baseline levels of streptococcal antibodies. RESULTS:
Significant group differences were found on several variables, such that children in whom …
OBJECTIVE
To explore associated clinical factors in children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS).
STUDY DESIGN
Children with tics, obsessive-compulsive disorder, or both (n=109) were examined with personal and family history, diagnostic interview, physical examination, medical record review, and measurement of baseline levels of streptococcal antibodies.
RESULTS
Significant group differences were found on several variables, such that children in whom PANDAS (versus without PANDAS) were more likely to have had dramatic onset, definite remissions, remission of neuropsychiatric symptoms during antibiotic therapy, a history of tonsillectomies/adenoidectomies, evidence of group A streptococcal infection, and clumsiness.
CONCLUSION
The identification of clinical features associated with PANDAS should assist in delineating risks for this subtype of obsessive-compulsive disorder/tics.
Elsevier