Myoblast fusion contributes to muscle growth in development and during regeneration of
mature muscle. Myoblasts fuse to each other as well as to multinucleate myotubes to
enlarge the myofiber. The molecular mechanisms of myoblast fusion are incompletely
understood. Adhesion, apposition, and membrane fusion are accompanied by cytoskeletal
rearrangements. The ferlin family of proteins is implicated in human muscle disease and has
been implicated in fusion events in muscle, including myoblast fusion, vesicle trafficking and …