[HTML][HTML] Immunoproteasomes are important for proteostasis in immune responses
F Ebstein, A Voigt, N Lange, A Warnatsch, F Schröter… - Cell, 2013 - cell.com
F Ebstein, A Voigt, N Lange, A Warnatsch, F Schröter, T Prozorovski, U Kuckelkorn, O Aktas…
Cell, 2013•cell.comThe regulated degradation of ubiquitin (ub)-tagged proteins by the ubiquitin proteasome
system (UPS) represents a major pathway not only for the maintenance of proteostasis, but
also for supplying peptides for MHC class I antigen presentation. This immune function of
the UPS can be improved by the immunoproteasome (IP), an isoenzyme of the 26S
proteasome with altered and enhanced peptide hydrolyzing activity (Figures 1 A and 1E)(
system (UPS) represents a major pathway not only for the maintenance of proteostasis, but
also for supplying peptides for MHC class I antigen presentation. This immune function of
the UPS can be improved by the immunoproteasome (IP), an isoenzyme of the 26S
proteasome with altered and enhanced peptide hydrolyzing activity (Figures 1 A and 1E)(
The regulated degradation of ubiquitin (ub)-tagged proteins by the ubiquitin proteasome system (UPS) represents a major pathway not only for the maintenance of proteostasis, but also for supplying peptides for MHC class I antigen presentation. This immune function of the UPS can be improved by the immunoproteasome (IP), an isoenzyme of the 26S proteasome with altered and enhanced peptide hydrolyzing activity (Figures 1 A and 1E)(
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