Inflammatory responses in influenza A virus infection
I Julkunen, K Melén, M Nyqvist, J Pirhonen, T Sareneva… - Vaccine, 2000 - Elsevier
I Julkunen, K Melén, M Nyqvist, J Pirhonen, T Sareneva, S Matikainen
Vaccine, 2000•ElsevierInfluenza A virus causes respiratory tract infections, which are occasionally complicated by
secondary bacterial infections. Influenza A virus replicates in epithelial cells and leukocytes
resulting in the production of chemokines and cytokines, which favor the extravasation of
blood mononuclear cells and the development of antiviral and Th1-type immune response.
Influenza A virus-infected respiratory epithelial cells produce limited amounts of chemokines
(RANTES, MCP-1, IL-8) and IFN-α/β, whereas monocytes/macrophages readily produce …
secondary bacterial infections. Influenza A virus replicates in epithelial cells and leukocytes
resulting in the production of chemokines and cytokines, which favor the extravasation of
blood mononuclear cells and the development of antiviral and Th1-type immune response.
Influenza A virus-infected respiratory epithelial cells produce limited amounts of chemokines
(RANTES, MCP-1, IL-8) and IFN-α/β, whereas monocytes/macrophages readily produce …
Influenza A virus causes respiratory tract infections, which are occasionally complicated by secondary bacterial infections. Influenza A virus replicates in epithelial cells and leukocytes resulting in the production of chemokines and cytokines, which favor the extravasation of blood mononuclear cells and the development of antiviral and Th1-type immune response. Influenza A virus-infected respiratory epithelial cells produce limited amounts of chemokines (RANTES, MCP-1, IL-8) and IFN-α/β, whereas monocytes/macrophages readily produce chemokines such as RANTES, MIP-1α, MCP-1, MCP-3, IP-10 and cytokines TNF-α, IL-1β, IL-6, IL-18 and IFN-α/β. The role of influenza A virus-induced inflammatory response in relation to otitis media is being discussed.
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