Vascular endothelial growth factor serum level is strongly enhanced after burn injury and correlated with local and general tissue edema

M Infanger, O Schmidt, P Kossmehl, S Grad, W Ertel… - Burns, 2004 - Elsevier
Background: Burn associated local and general tissue edema is induced by local cell
destruction and capillary leak syndrome. Vascular endothelial growth factor (VEGF) strongly
enhances vascular permeability as well as angiogenesis. The principal aim of this study was
to investigate the systemic release of VEGF and its kinetics after severe burn injury in
humans. Methods: Thirty-six burn patients and 42 healthy volunteers were enrolled in this
study. Circulating VEGF serum levels were measured by enzyme-linked immunosorbent …