Protein arginine methylation of non-histone proteins and its role in diseases

H Wei, R Mundade, K Lange, T Lu - Cell cycle, 2014 - Taylor & Francis
H Wei, R Mundade, K Lange, T Lu
Cell cycle, 2014Taylor & Francis
Protein arginine methyltransferases (PRMTs) are a family of enzymes that can methylate
arginine residues on histones and other proteins. PRMTs play a crucial role in influencing
various cellular functions, including cellular development and tumorigenesis. Arginine
methylation by PRMTs is found on both nuclear and cytoplasmic proteins. Recently, there is
increasing evidence regarding post-translational modifications of non-histone proteins by
PRMTs, illustrating the previously unknown importance of PRMTs in the regulation of …
Protein arginine methyltransferases (PRMTs) are a family of enzymes that can methylate arginine residues on histones and other proteins. PRMTs play a crucial role in influencing various cellular functions, including cellular development and tumorigenesis. Arginine methylation by PRMTs is found on both nuclear and cytoplasmic proteins. Recently, there is increasing evidence regarding post-translational modifications of non-histone proteins by PRMTs, illustrating the previously unknown importance of PRMTs in the regulation of various cellular functions by post-translational modifications. In this review, we present the recent developments in the regulation of non-histone proteins by PRMTs.
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