The effect of starvation on the concentration and binding of thyroxine and triiodothyronine in serum and on the response to TRH
GI Portnay, JT O'Brian, J Bush… - The Journal of …, 1974 - academic.oup.com
GI Portnay, JT O'Brian, J Bush, AG Vagenakis, F Azizi, RA Arky, SH Ingbar, LE Braverman
The Journal of Clinical Endocrinology & Metabolism, 1974•academic.oup.comIn 9 euthyroid obese volunteers, 4 weeks of total caloric deprivation resulted in striking
decreases in both total and free triiodothyronine (T3) concentrations in serum together with a
slight increase in free thyroxine (T4) concentration. These changes were not associated with
alterations in the basal serum TSH concentration or in the TSH or T3 responses to
exogenous TRH. It is suggested that the decrease in serum T3 concentration that occurs
during starvation results from decreased peripheral conversion of T4 to T3 and may explain …
decreases in both total and free triiodothyronine (T3) concentrations in serum together with a
slight increase in free thyroxine (T4) concentration. These changes were not associated with
alterations in the basal serum TSH concentration or in the TSH or T3 responses to
exogenous TRH. It is suggested that the decrease in serum T3 concentration that occurs
during starvation results from decreased peripheral conversion of T4 to T3 and may explain …
Abstract
In 9 euthyroid obese volunteers, 4 weeks of total caloric deprivation resulted in striking decreases in both total and free triiodothyronine (T3) concentrations in serum together with a slight increase in free thyroxine (T4) concentration. These changes were not associated with alterations in the basal serum TSH concentration or in the TSH or T3 responses to exogenous TRH. It is suggested that the decrease in serum T3 concentration that occurs during starvation results from decreased peripheral conversion of T4 to T3 and may explain, at least partially, the decreased serum T3 seen in clinical states associated with inanition.
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