[HTML][HTML] Architectural nucleoporins Nup157/170 and Nup133 are structurally related and descend from a second ancestral element
JRR Whittle, TU Schwartz - Journal of biological chemistry, 2009 - ASBMB
The nuclear pore complex (NPC) constitutes one of the largest protein assemblies in the
eukaryotic cell and forms the exclusive gateway to the nucleus. The stable,∼ 15–20-MDa
scaffold ring of the NPC is built from two multiprotein complexes arranged around a central 8-
fold axis. Here we present crystal structures of two large architectural units, yNup170 979–
1502 and hNup107 658–925· hNup133 517–1156, each a constituent of one of the two
multiprotein complexes. Conservation of domain arrangement and of tertiary structure …
eukaryotic cell and forms the exclusive gateway to the nucleus. The stable,∼ 15–20-MDa
scaffold ring of the NPC is built from two multiprotein complexes arranged around a central 8-
fold axis. Here we present crystal structures of two large architectural units, yNup170 979–
1502 and hNup107 658–925· hNup133 517–1156, each a constituent of one of the two
multiprotein complexes. Conservation of domain arrangement and of tertiary structure …