Defective nuclear translocation of nuclear factor of activated T cells and extracellular signal-regulated kinase underlies deficient IL-2 gene expression in Wiskott …
BACKGROUND: Proliferation and IL-2 production in response to T-cell receptor ligation are
impaired in patients with Wiskott-Aldrich syndrome (WAS). The transcription factors nuclear
factor-κB (NF-κB), nuclear factor of activated T cells (NF-AT), and activating protein-1 (AP-1)
play a critical role in IL-2 gene expression. OBJECTIVE: To investigate the mechanisms of
impaired IL-2 production after T-cell receptor ligation in T cells deficient in WAS protein
(WASP). METHODS: T cells from WASP−/− mice were stimulated with anti-CD3 and anti …
impaired in patients with Wiskott-Aldrich syndrome (WAS). The transcription factors nuclear
factor-κB (NF-κB), nuclear factor of activated T cells (NF-AT), and activating protein-1 (AP-1)
play a critical role in IL-2 gene expression. OBJECTIVE: To investigate the mechanisms of
impaired IL-2 production after T-cell receptor ligation in T cells deficient in WAS protein
(WASP). METHODS: T cells from WASP−/− mice were stimulated with anti-CD3 and anti …