Serum hyaluronan-a non-invasive test for diagnosing liver cirrhosis
JN Plevris, GH Haydon, KJ Simpson… - European journal of …, 2000 - journals.lww.com
Introduction: Hyaluronan is a glucosaminoglycan synthesized by the mesenchymal cells and
degraded by hepatic sinusoidal endothelial cells by a specific receptor-mediated process.
Elevated levels are associated with the sinusoidal capillarization that is seen in cirrhosis.
Methodology: Serum hyaluronan was measured, using a radiometric assay (Pharmacia,
Sweden) in 221 patients with biopsy-proven chronic liver disease of a variety of aetiologies
(alcohol n= 70, autoimmune chronic active hepatitis n= 23, primary biliary cirrhosis n= 17 …
degraded by hepatic sinusoidal endothelial cells by a specific receptor-mediated process.
Elevated levels are associated with the sinusoidal capillarization that is seen in cirrhosis.
Methodology: Serum hyaluronan was measured, using a radiometric assay (Pharmacia,
Sweden) in 221 patients with biopsy-proven chronic liver disease of a variety of aetiologies
(alcohol n= 70, autoimmune chronic active hepatitis n= 23, primary biliary cirrhosis n= 17 …