[PDF][PDF] Mutations and deletions of the TP53 gene predict nonresponse to treatment and poor outcome in first relapse of childhood acute lymphoblastic leukemia

J Hof, S Krentz, C Van Schewick, G Korner… - J Clin …, 2011 - researchgate.net
J Hof, S Krentz, C Van Schewick, G Korner, S Shalapour, P Rhein, L Karawajew, WD Ludwig…
J Clin Oncol, 2011researchgate.net
Purpose In the clinical management of children with relapsed acute lymphoblastic leukemia
(ALL), treatment resistance remains a major challenge. Alterations of the TP53 gene are
frequently associated with resistance to chemotherapy, but their significance in relapsed
childhood ALL has remained controversial because of small studies.
Purpose
In the clinical management of children with relapsed acute lymphoblastic leukemia (ALL), treatment resistance remains a major challenge. Alterations of the TP53 gene are frequently associated with resistance to chemotherapy, but their significance in relapsed childhood ALL has remained controversial because of small studies.
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