Role of cytogenetics in hematology

JD Rowley - Blood;(United States), 1976 - osti.gov
JD Rowley
Blood;(United States), 1976osti.gov
Evidence is accumulating that various nonrandom chromosomal patterns are found in
myeloproliferative disorders. Although none of these patterns shows the same degree of
specificity as the Ph/sup 1/chromosome in CML, their detection lends support to the
hypothesis that chromosomal changes play an important role in these diseases.
Chromosomal analysis of bone marrow cells by use of banding techniques has become an
integral part of the careful investigation of virtually any group of patients with a particular …
Evidence is accumulating that various nonrandom chromosomal patterns are found in myeloproliferative disorders. Although none of these patterns shows the same degree of specificity as the Ph/sup 1/ chromosome in CML, their detection lends support to the hypothesis that chromosomal changes play an important role in these diseases. Chromosomal analysis of bone marrow cells by use of banding techniques has become an integral part of the careful investigation of virtually any group of patients with a particular hematologic disorder and may prove useful in guiding the clinician in the prognosis and therapy of these disorders. The correlation of the clinical findings with the cytogenetic, morphological, and biochemical analyses will provide a much more complete understanding of these diseases than can be achieved with any one of these techniques used alone.
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