In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases

S Seki, T Kitada, T Yamada, H Sakaguchi… - Journal of …, 2002 - Elsevier
Background/Aims: Although oxidative stress is an important candidate in the pathogenesis
of non-alcoholic fatty liver disease (NAFLD), the localization and pathological significance of
oxidative stress-induced cellular damage in NAFLD remains unclear. Methods: Hepatic
expression of 4-hydroxy-2′-nonenal (HNE) and 8-hydroxydeoxyguanosine (8-OHdG), as
reliable markers of lipid peroxidation and oxidative DNA damage, respectively, was
immunohistochemically investigated in NAFLD and the results were compared with …