[HTML][HTML] 2′-O-(2-Methoxy) ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit …
BF Baker, SS Lot, TP Condon… - Journal of Biological …, 1997 - ASBMB
Little is known about the mechanisms that account for inhibition of gene expression by
antisense oligonucleotides at the level of molecular cell biology. For this purpose, we have
selected potent 2′-O-(2-methoxy) ethyl antisense oligonucleotides (IC 50= 2 and 6 nm) that
target the 5′ cap region of the human intercellular adhesion molecule 1 (ICAM-1) transcript
to determine their effects upon individual processes of mRNA metabolism in HUVECs. Given
the functions of the 5′ cap structure throughout mRNA metabolism, antisense …
antisense oligonucleotides at the level of molecular cell biology. For this purpose, we have
selected potent 2′-O-(2-methoxy) ethyl antisense oligonucleotides (IC 50= 2 and 6 nm) that
target the 5′ cap region of the human intercellular adhesion molecule 1 (ICAM-1) transcript
to determine their effects upon individual processes of mRNA metabolism in HUVECs. Given
the functions of the 5′ cap structure throughout mRNA metabolism, antisense …