Previous studies have reported that the intrathecal (it) administration of transforming growth
factor β1 (TGF-β1) prevents and reverses neuropathic pain. However, only limited
information is available regarding the possible role and effects of spinal TGF-β1 in
neuropathic pain. We aimed to investigate the antinociceptive effects of exogenous TGF-β1
on chronic constriction injury (CCI)-induced neuropathic pain in rats. We demonstrated that
sciatic nerve injury caused a downregulation of endogenous TGF-β1 levels on the ipsilateral …