IP3 Receptor Types 2 and 3 Mediate Exocrine Secretion Underlying Energy Metabolism
A Futatsugi, T Nakamura, MK Yamada, E Ebisui… - Science, 2005 - science.org
Science, 2005•science.org
Type 2 and type 3 inositol 1, 4, 5-trisphosphate receptors (IP3R2 and IP3R3) are
intracellular calcium-release channels whose physiological roles are unknown. We show
exocrine dysfunction in IP3R2 and IP3R3 double knock-out mice, which caused difficulties in
nutrient digestion. Severely impaired calcium signaling in acinar cells of the salivary glands
and the pancreas in the double mutants ascribed the secretion deficits to a lack of
intracellular calcium release. Despite a normal caloric intake, the double mutants were …
intracellular calcium-release channels whose physiological roles are unknown. We show
exocrine dysfunction in IP3R2 and IP3R3 double knock-out mice, which caused difficulties in
nutrient digestion. Severely impaired calcium signaling in acinar cells of the salivary glands
and the pancreas in the double mutants ascribed the secretion deficits to a lack of
intracellular calcium release. Despite a normal caloric intake, the double mutants were …
Type 2 and type 3 inositol 1,4,5-trisphosphate receptors (IP3R2 and IP3R3) are intracellular calcium-release channels whose physiological roles are unknown. We show exocrine dysfunction in IP3R2 and IP3R3 double knock-out mice, which caused difficulties in nutrient digestion. Severely impaired calcium signaling in acinar cells of the salivary glands and the pancreas in the double mutants ascribed the secretion deficits to a lack of intracellular calcium release. Despite a normal caloric intake, the double mutants were hypoglycemic and lean. These results reveal IP3R2 and IP3R3 as key molecules in exocrine physiology underlying energy metabolism and animal growth.
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