Asthma is a common respiratory disease affecting∼ 300 million people worldwide. Airway
inflammation is thought to contribute to asthma pathogenesis, but the direct relationship
between inflammation and airway hyperresponsiveness (AHR) remains unclear. This study
investigates the role of inflammation in a steroid-insensitive, severe allergic airway disease
model and in severe asthmatics stratified by inflammatory profile. First, we used the T-helper
(TH)-17 cells adoptive transfer mouse model of asthma to induce pulmonary inflammation …