1. Kinetic Characteristics of Glucokinase and Glucose Metabolism by Islets.................................................................... 176 2. Inhibition of Glucokinase by Pharmacologic Agents............... 177 3. Variation in Islet Glucokinase Activity with Physiologi Different Species....................................................... 178 4. Discrimination of Hexose Anomers.................. 179 5. Effect of Fructose on Glucose Metabolism....................... 181 D. Anomeric Discrimination in the Glycolytic Pathway....................... 182 E. Regulation of Phosphofructokinase........................................ 185 F. Regulation of Glucose Metabolism in the Lower Glycolytic Pathway. G. Fate of Pyruvate in Pancreatic Islets....................................... 191 IV. Relationship Between Oxidative Metbolism and Insulin Secretion............ 195 A. Generation of a Signal for Insulin Secretion in the Lower Portion of the Glycolytic Pathway........................................................ 199 B. Regulation of Metabolism of Endogenous Fuels........................... 199