CD1d-restricted natural killer T cells contribute to hepatic inflammation and fibrogenesis in mice
S Ishikawa, K Ikejima, H Yamagata, T Aoyama… - Journal of …, 2011 - Elsevier
BACKGROUND & AIMS: Several lines of evidence suggest that innate immunity plays a key
role in hepatic fibrogenesis. To clarify the role of natural killer (NK) T cells in hepatic
inflammation and fibrogenesis, we here investigated xenobiotics-induced liver injury and
subsequent fibrogenesis in mice lacking mature NKT cells caused by genetic disruption of
the CD1d molecule. METHODS: Male CD1d-knockout (KO) and wild-type (WT) mice were
given repeated intraperitoneal injections of thioacetamide (TAA, 3times/week; 0.1–0.2 mg/g …
role in hepatic fibrogenesis. To clarify the role of natural killer (NK) T cells in hepatic
inflammation and fibrogenesis, we here investigated xenobiotics-induced liver injury and
subsequent fibrogenesis in mice lacking mature NKT cells caused by genetic disruption of
the CD1d molecule. METHODS: Male CD1d-knockout (KO) and wild-type (WT) mice were
given repeated intraperitoneal injections of thioacetamide (TAA, 3times/week; 0.1–0.2 mg/g …