Fetal programming of hypothalamic–pituitary–adrenal (HPA) axis function and behavior by synthetic glucocorticoids
A Kapoor, S Petropoulos, SG Matthews - Brain research reviews, 2008 - Elsevier
Reduced fetal growth has been closely associated with an increased risk for the
development of chronic disease in later life. Accumulating evidence indicates that fetal
exposure to excess glucocorticoids represents a critical mechanism underlying this
association. Approximately 7% of pregnant women are at risk of preterm delivery and these
women are routinely treated with synthetic glucocorticoids (sGC) between 24 and 34 of
weeks gestation to improve neonatal outcome. Animal studies have demonstrated that …
development of chronic disease in later life. Accumulating evidence indicates that fetal
exposure to excess glucocorticoids represents a critical mechanism underlying this
association. Approximately 7% of pregnant women are at risk of preterm delivery and these
women are routinely treated with synthetic glucocorticoids (sGC) between 24 and 34 of
weeks gestation to improve neonatal outcome. Animal studies have demonstrated that …