[HTML][HTML] Cross-talk between remodeling and de novo pathways maintains phospholipid balance through ubiquitination
PL Butler, RK Mallampalli - Journal of biological chemistry, 2010 - ASBMB
Phosphatidylcholine (PtdCho), the major phospholipid of animal membranes, is generated
by its remodeling and de novo synthesis. Overexpression of the remodeling enzyme,
LPCAT1 (acyl-CoA: lysophosphatidylcholine acyltransferase) in epithelia decreased de
novo PtdCho synthesis without significantly altering cellular PtdCho mass. Overexpression
of LPCAT1 increased degradation of CPT1 (cholinephosphotransferase), a resident Golgi
enzyme that catalyzes the terminal step for de novo PtdCho synthesis. CPT1 degradation …
by its remodeling and de novo synthesis. Overexpression of the remodeling enzyme,
LPCAT1 (acyl-CoA: lysophosphatidylcholine acyltransferase) in epithelia decreased de
novo PtdCho synthesis without significantly altering cellular PtdCho mass. Overexpression
of LPCAT1 increased degradation of CPT1 (cholinephosphotransferase), a resident Golgi
enzyme that catalyzes the terminal step for de novo PtdCho synthesis. CPT1 degradation …