[HTML][HTML] Liver-specific p70 S6 kinase depletion protects against hepatic steatosis and systemic insulin resistance
EJ Bae, J Xu, G Bandyopadhyay, WS Lagakos… - Journal of Biological …, 2012 - ASBMB
Obesity-associated hepatic steatosis is a manifestation of selective insulin resistance
whereby lipogenesis remains sensitive to insulin but the ability of insulin to suppress
glucose production is impaired. We created a mouse model of liver-specific knockdown of
p70 S6 kinase (S6K)(L-S6K-KD) by systemic delivery of an adeno-associated virus carrying
a shRNA for S6K and examined the effects on steatosis and insulin resistance. High fat diet
(HFD) fed L-S6K-KD mice showed improved glucose tolerance and systemic insulin …
whereby lipogenesis remains sensitive to insulin but the ability of insulin to suppress
glucose production is impaired. We created a mouse model of liver-specific knockdown of
p70 S6 kinase (S6K)(L-S6K-KD) by systemic delivery of an adeno-associated virus carrying
a shRNA for S6K and examined the effects on steatosis and insulin resistance. High fat diet
(HFD) fed L-S6K-KD mice showed improved glucose tolerance and systemic insulin …