[HTML][HTML] Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra
Experimental neurology, 2013•Elsevier
The presynaptic protein α-synuclein is central to the pathogenesis of α-synucleinopathies.
We show that the presence of endogenous mouse α-synuclein leads to higher number of
dopaminergic neurons in the substantia nigra of wild-type C57Bl/6J mice compared with
C57Bl/6S mice with a spontaneous deletion of the α-synuclein gene or C57Bl/6J mice with a
targeted deletion of the α-synuclein gene. This effect of α-synuclein on dopaminergic neuron
occurs during development between E10. 5 and E13. 5 and persists in adult life supporting …
We show that the presence of endogenous mouse α-synuclein leads to higher number of
dopaminergic neurons in the substantia nigra of wild-type C57Bl/6J mice compared with
C57Bl/6S mice with a spontaneous deletion of the α-synuclein gene or C57Bl/6J mice with a
targeted deletion of the α-synuclein gene. This effect of α-synuclein on dopaminergic neuron
occurs during development between E10. 5 and E13. 5 and persists in adult life supporting …
Abstract
The presynaptic protein α-synuclein is central to the pathogenesis of α-synucleinopathies. We show that the presence of endogenous mouse α-synuclein leads to higher number of dopaminergic neurons in the substantia nigra of wild-type C57Bl/6J mice compared with C57Bl/6S mice with a spontaneous deletion of the α-synuclein gene or C57Bl/6J mice with a targeted deletion of the α-synuclein gene. This effect of α-synuclein on dopaminergic neuron occurs during development between E10.5 and E13.5 and persists in adult life supporting the involvement of α-synuclein in the development of a subset of dopaminergic neurons.
Elsevier