Broad-spectrum analgesic efficacy of IBNtxA is mediated by exon 11-associated splice variants of the mu-opioid receptor gene
Abstract μ-Opioids remain vastly important for the treatment of pain, and would represent
ideal analgesics if their analgesic effects could be separated from their many side effects. A
recently synthesized compound, iodobenzoylnaltrexamide (IBNtxA), acting at 6-
transmembrane (6-TM) splice variants of the μ-opioid receptor gene, was shown to have
potent analgesic actions against acute, thermal pain accompanied by a vastly improved side-
effect profile compared to 7-TM-acting drugs such as morphine. Whether such analgesia can …
ideal analgesics if their analgesic effects could be separated from their many side effects. A
recently synthesized compound, iodobenzoylnaltrexamide (IBNtxA), acting at 6-
transmembrane (6-TM) splice variants of the μ-opioid receptor gene, was shown to have
potent analgesic actions against acute, thermal pain accompanied by a vastly improved side-
effect profile compared to 7-TM-acting drugs such as morphine. Whether such analgesia can …