[HTML][HTML] RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation

PP Roux, D Shahbazian, H Vu, MK Holz… - Journal of Biological …, 2007 - ASBMB
Converging signals from the mammalian target of rapamycin (mTOR) and phosphoinositide
3-kinase (PI3K) pathways are well established to modulate translation initiation. Less is
known regarding the molecular basis of protein synthesis regulated by other inputs, such as
agonists of the Ras/extracellular signal-regulated kinase (ERK) signaling cascade.
Ribosomal protein (rp) S6 is a component of the 40S ribosomal subunit that becomes
phosphorylated at several serine residues upon mitogen stimulation, but the exact molecular …