Nutrient-sensing signaling pathways regulate cell metabolism and growth in response to
altered nutrient levels and growth factor signaling. Because trophoblast cell metabolism and
associated signaling influence fetal nutrient availability, trophoblast nutrient sensors may
have a unique role in regulating fetal growth. We review data in support of a role for
mammalian target of rapamycin complex 1 (mTORC1) in placental nutrient-sensing.
Placental insulin/IGF-I signaling and fetal levels of oxygen, glucose and amino acids (AAs) …