Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity
K Bryniarski, W Ptak, A Jayakumar, K Püllmann… - Journal of Allergy and …, 2013 - Elsevier
Background T-cell tolerance of allergic cutaneous contact sensitivity (CS) induced in mice by
high doses of reactive hapten is mediated by suppressor cells that release antigen-specific
suppressive nanovesicles. Objective We sought to determine the mechanism or
mechanisms of immune suppression mediated by the nanovesicles. Methods T-cell
tolerance was induced by means of intravenous injection of hapten conjugated to self-
antigens of syngeneic erythrocytes and subsequent contact immunization with the same …
high doses of reactive hapten is mediated by suppressor cells that release antigen-specific
suppressive nanovesicles. Objective We sought to determine the mechanism or
mechanisms of immune suppression mediated by the nanovesicles. Methods T-cell
tolerance was induced by means of intravenous injection of hapten conjugated to self-
antigens of syngeneic erythrocytes and subsequent contact immunization with the same …