[HTML][HTML] Clinical grade manufacturing of human alloantigen-reactive regulatory T cells for use in transplantation
AL Putnam, N Safinia, A Medvec, M Laszkowska… - American journal of …, 2013 - Elsevier
Regulatory T cell (Treg) therapy has the potential to induce transplantation tolerance so that
immunosuppression and associated morbidity can be minimized. Alloantigen-reactive Tregs
(arTregs) are more effective at preventing graft rejection than polyclonally expanded Tregs
(PolyTregs) in murine models. We have developed a manufacturing process to expand
human arTregs in short-term cultures using good manufacturing practice-compliant
reagents. This process uses CD40L-activated allogeneic B cells to selectively expand …
immunosuppression and associated morbidity can be minimized. Alloantigen-reactive Tregs
(arTregs) are more effective at preventing graft rejection than polyclonally expanded Tregs
(PolyTregs) in murine models. We have developed a manufacturing process to expand
human arTregs in short-term cultures using good manufacturing practice-compliant
reagents. This process uses CD40L-activated allogeneic B cells to selectively expand …