A novel mechanism of action for anti-thymocyte globulin: induction of CD4:+: CD25:+: foxp3:+: regulatory T cells
M Lopez, MR Clarkson, M Albin… - Journal of the …, 2006 - journals.lww.com
T cell–depleting agents are being tested as part of clinical tolerance strategies in humans
with autoimmunity and transplantation. The immunosuppressive activity of anti-thymocyte
globulin (ATG) has been thought to result primarily from depletion of peripheral lymphocytes.
Herein is reported for the first time that ATG but not anti-CD52 mAb (alemtuzumab) or the IL-
2R antagonists causes rapid and sustained expansion of CD4+ CD25+ T cells when
cultured with human peripheral blood lymphocytes. These cells display enhanced …
with autoimmunity and transplantation. The immunosuppressive activity of anti-thymocyte
globulin (ATG) has been thought to result primarily from depletion of peripheral lymphocytes.
Herein is reported for the first time that ATG but not anti-CD52 mAb (alemtuzumab) or the IL-
2R antagonists causes rapid and sustained expansion of CD4+ CD25+ T cells when
cultured with human peripheral blood lymphocytes. These cells display enhanced …