Cholesterol is implicated to play a role in Alzheimer disease pathology. Therefore, the
concentrations of cholesterol, its precursors, and its degradation products in brain
homogenates of aging wild-type and β-amyloid precursor protein transgenic mice carrying
the Swedish mutation (APP23) were analyzed. Among the sterols measured, lanosterol is
the first common intermediate of two different pathways, which use either desmosterol or
lathosterol as the predominant precursors for de novo synthesis of brain cholesterol. In …