Evidence for cyclic diguanylate as a vaccine adjuvant with novel immunostimulatory activities
PM Gray, G Forrest, T Wisniewski, G Porter… - Cellular …, 2012 - Elsevier
Cyclic diguanylate (c-di-GMP), a bacterial signaling molecule, possesses protective
immunostimulatory activity in bacterial challenge models. This study explored the potential
of c-di-GMP as a vaccine adjuvant comparing it with LPS, CpG oligonucleotides, and a
conventional aluminum salt based adjuvant. In this evaluation, c-di-GMP was a more potent
activator of both humoral and Th1-like immune responses as evidenced by the robust IgG2a
antibody response it induced in mice and the strong IFN-γ, TNF-α and IP-10 responses, it …
immunostimulatory activity in bacterial challenge models. This study explored the potential
of c-di-GMP as a vaccine adjuvant comparing it with LPS, CpG oligonucleotides, and a
conventional aluminum salt based adjuvant. In this evaluation, c-di-GMP was a more potent
activator of both humoral and Th1-like immune responses as evidenced by the robust IgG2a
antibody response it induced in mice and the strong IFN-γ, TNF-α and IP-10 responses, it …