[PDF][PDF] SnapShot: the germinal center reaction
GD Victora - Cell, 2014 - cell.com
Cell, 2014•cell.com
To produce high-affinity antibodies, B cells must undergo iterative cycles of targeted
mutagenesis and affinity-based selection. These cycles take place in a structure known as
the germinal center, which forms in secondary lymphoid organs upon exposure to antigenic
stimuli. Here, we summarize our current understanding of the germinal center reaction.
mutagenesis and affinity-based selection. These cycles take place in a structure known as
the germinal center, which forms in secondary lymphoid organs upon exposure to antigenic
stimuli. Here, we summarize our current understanding of the germinal center reaction.
To produce high-affinity antibodies, B cells must undergo iterative cycles of targeted mutagenesis and affinity-based selection. These cycles take place in a structure known as the germinal center, which forms in secondary lymphoid organs upon exposure to antigenic stimuli. Here, we summarize our current understanding of the germinal center reaction.
cell.com