[HTML][HTML] Age-associated skewing of X-inactivation ratios of blood cells in normal females: a candidate-gene analysis approach
P Chagnon, S Provost, C Belisle, V Bolduc… - Experimental …, 2005 - Elsevier
X-inactivation is a random process that occurs in females early during embryogenesis.
Females are mosaics with an equal proportion of cells with the paternal (Xp) or maternal X-
chromosome (Xm) in the active state. However, close to 40% of healthy females aged more
than 60 yo present a significant skewing of X-inactivation ratios (Xp: Xm> 3: 1). The exact
etiology of this age-associated skewing (AAS) in blood cells is unknown. We hypothesized
that AAS is due to hemizygous cell selection caused by allelic variants in hematopoiesis or …
Females are mosaics with an equal proportion of cells with the paternal (Xp) or maternal X-
chromosome (Xm) in the active state. However, close to 40% of healthy females aged more
than 60 yo present a significant skewing of X-inactivation ratios (Xp: Xm> 3: 1). The exact
etiology of this age-associated skewing (AAS) in blood cells is unknown. We hypothesized
that AAS is due to hemizygous cell selection caused by allelic variants in hematopoiesis or …