[HTML][HTML] Effect of glycosphingolipids on osteoclastogenesis and osteolytic bone diseases
A Ersek, A Karadimitris, NJ Horwood - Frontiers in endocrinology, 2012 - frontiersin.org
A Ersek, A Karadimitris, NJ Horwood
Frontiers in endocrinology, 2012•frontiersin.orgAlterations in glycosphingolipid (GSL) production results in lysosomal storage disorders
associated with neurodegenerative changes. In Gaucher's disease, the patients also
develop osteoporosis that is ameliorated upon treatment for the underlying defect in GSL
metabolism. The role of GSLs in osteoclast and osteoblast formation is discussed here as
well as the potential therapeutic uses of already approved drugs that limit GSL production in
bone loss disorders such as multiple myeloma and periodontal disease.
associated with neurodegenerative changes. In Gaucher's disease, the patients also
develop osteoporosis that is ameliorated upon treatment for the underlying defect in GSL
metabolism. The role of GSLs in osteoclast and osteoblast formation is discussed here as
well as the potential therapeutic uses of already approved drugs that limit GSL production in
bone loss disorders such as multiple myeloma and periodontal disease.
Alterations in glycosphingolipid (GSL) production results in lysosomal storage disorders associated with neurodegenerative changes. In Gaucher’s disease, the patients also develop osteoporosis that is ameliorated upon treatment for the underlying defect in GSL metabolism. The role of GSLs in osteoclast and osteoblast formation is discussed here as well as the potential therapeutic uses of already approved drugs that limit GSL production in bone loss disorders such as multiple myeloma and periodontal disease.
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