Luteinizing hormone-releasing hormone (LHRH)-expressing cells do not migrate normally in an inherited hypogonadal (Kallmann) syndrome
M Schwanzel-Fukuda, D Bick, DW Pfaff - Molecular Brain Research, 1989 - Elsevier
Kallmann syndrome inherited hypogonadotropic hypogonadism with anosmia, is associated
with an X-chromosome deletion at Xp 22.3. In a Kallmann fetus, we have found an absence
of luteinizing hormone-releasing hormone (LHRH)-expressing cells in the brain despite
dense clusters of LHRH cells and fibers in the nose. LHRH-containing cells and neurites
end in a tangle beneath the forebrain, within the dural layers of the meninges, on the dorsal
surface of the cribriform plate of the ethmoid bone. Normal fetal brains, matched for age and …
with an X-chromosome deletion at Xp 22.3. In a Kallmann fetus, we have found an absence
of luteinizing hormone-releasing hormone (LHRH)-expressing cells in the brain despite
dense clusters of LHRH cells and fibers in the nose. LHRH-containing cells and neurites
end in a tangle beneath the forebrain, within the dural layers of the meninges, on the dorsal
surface of the cribriform plate of the ethmoid bone. Normal fetal brains, matched for age and …