[HTML][HTML] Low density lipoprotein binds to proprotein convertase subtilisin/kexin type-9 (PCSK9) in human plasma and inhibits PCSK9-mediated low density lipoprotein …
Proprotein convertase subtilisin/kexin type-9 (PCSK9) is a secreted protein that binds to the
epidermal growth factor-like-A domain of the low density lipoprotein receptor (LDLR) and
mediates LDLR degradation in liver. Gain-of-function mutations in PCSK9 are associated
with autosomal dominant hypercholesterolemia in humans. Size-exclusion chromatography
of human plasma has shown PCSK9 to be partly associated with undefined high molecular
weight complexes within the LDL size range. We used density gradient centrifugation to …
epidermal growth factor-like-A domain of the low density lipoprotein receptor (LDLR) and
mediates LDLR degradation in liver. Gain-of-function mutations in PCSK9 are associated
with autosomal dominant hypercholesterolemia in humans. Size-exclusion chromatography
of human plasma has shown PCSK9 to be partly associated with undefined high molecular
weight complexes within the LDL size range. We used density gradient centrifugation to …