Ubiquitin deposits in anterior horn cells in motor neurone disease
PN Leigh, BH Anderton, A Dodson, JM Gallo… - Neuroscience …, 1988 - Elsevier
PN Leigh, BH Anderton, A Dodson, JM Gallo, M Swash, DM Power
Neuroscience letters, 1988•ElsevierA polyclonal antiserum to ubiquitin, a low molecular weight protein involved in the ATP-
dependent removal of abnormal cytoplasmic proteins, has been used to stain spinal cord
from 10 cases of motor neurone disease and from 12 control spinal cords. All 10 cases of
motor neurone disease exhibited antiubiquitin-immunoreactive deposits in a proportion of
the surviving anterior horn cells but these deposits were not seen in any of the 12 controls.
These ubiquitin deposits do not correspond to previously described neuronal inclusions in …
dependent removal of abnormal cytoplasmic proteins, has been used to stain spinal cord
from 10 cases of motor neurone disease and from 12 control spinal cords. All 10 cases of
motor neurone disease exhibited antiubiquitin-immunoreactive deposits in a proportion of
the surviving anterior horn cells but these deposits were not seen in any of the 12 controls.
These ubiquitin deposits do not correspond to previously described neuronal inclusions in …
Abstract
A polyclonal antiserum to ubiquitin, a low molecular weight protein involved in the ATP-dependent removal of abnormal cytoplasmic proteins, has been used to stain spinal cord from 10 cases of motor neurone disease and from 12 control spinal cords. All 10 cases of motor neurone disease exhibited antiubiquitin-immunoreactive deposits in a proportion of the surviving anterior horn cells but these deposits were not seen in any of the 12 controls. These ubiquitin deposits do not correspond to previously described neuronal inclusions in motor neurone disease. The ubiquitin deposits represent, therefore, a new neuronal inclusion which possibly reflects previously unrecognised degradative events occurring in the vulnerable neurones.
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