Acid-base balance and potassium disorders are often clinically linked. Importantly, acid-
base disorders alter potassium transport. In general, acidosis causes decreased K+
secretion and increased reabsorption in the collecting duct. Alkalosis has the opposite
effects, often leading to hypokalemia. Potassium disorders also influence acid-base
homeostasis. Potassium depletion causes increased H+ secretion, ammoniagenesis and
HK-ATPase activity. Hyperkalemia decreases ammoniagenesis and NH 4+ transport in the …