[HTML][HTML] Gene-lifestyle interaction and type 2 diabetes: the EPIC interact case-cohort study
PLoS medicine, 2014•journals.plos.org
In this study, Wareham and colleagues quantified the combined effects of genetic and
lifestyle factors on risk of T2D in order to inform strategies for prevention. The authors found
that the relative effect of a type 2 diabetes genetic risk score is greater in younger and leaner
participants, and the high absolute risk associated with obesity at any level of genetic risk
highlights the importance of universal rather than targeted approaches to lifestyle
intervention. Please see later in the article for the Editors' Summary
lifestyle factors on risk of T2D in order to inform strategies for prevention. The authors found
that the relative effect of a type 2 diabetes genetic risk score is greater in younger and leaner
participants, and the high absolute risk associated with obesity at any level of genetic risk
highlights the importance of universal rather than targeted approaches to lifestyle
intervention. Please see later in the article for the Editors' Summary
In this study, Wareham and colleagues quantified the combined effects of genetic and lifestyle factors on risk of T2D in order to inform strategies for prevention. The authors found that the relative effect of a type 2 diabetes genetic risk score is greater in younger and leaner participants, and the high absolute risk associated with obesity at any level of genetic risk highlights the importance of universal rather than targeted approaches to lifestyle intervention. Please see later in the article for the Editors' Summary
PLOS