Calcium signaling in pancreatic β-cells in health and in Type 2 diabetes
Abstract Changes in cytosolic free Ca 2+ concentration ([Ca 2+] c) play a crucial role in the
control of insulin secretion from the electrically excitable pancreatic β-cell. Secretion is
controlled by the finely tuned balance between Ca 2+ influx (mainly through voltage-
dependent Ca 2+ channels, but also through voltage-independent Ca 2+ channels like store-
operated channels) and efflux pathways. Changes in [Ca 2+] c directly affect [Ca 2+] in
various organelles including the endoplasmic reticulum (ER), mitochondria, the Golgi …
control of insulin secretion from the electrically excitable pancreatic β-cell. Secretion is
controlled by the finely tuned balance between Ca 2+ influx (mainly through voltage-
dependent Ca 2+ channels, but also through voltage-independent Ca 2+ channels like store-
operated channels) and efflux pathways. Changes in [Ca 2+] c directly affect [Ca 2+] in
various organelles including the endoplasmic reticulum (ER), mitochondria, the Golgi …