mTOR and cancer: many loops in one pathway
A Efeyan, DM Sabatini - Current opinion in cell biology, 2010 - Elsevier
A Efeyan, DM Sabatini
Current opinion in cell biology, 2010•ElsevierThe mammalian target of rapamycin (mTOR) is a master regulator of cell growth and division
that responds to a variety of stimuli, including nutrient, energy, and growth factors. In the last
years, a significant number of pieces have been added to the puzzle of how mTOR
coordinates and executes its functions. Extensive research on mTOR has also uncovered a
complex network of regulatory loops that impact the therapeutic approaches aimed at
targeting mTOR.
that responds to a variety of stimuli, including nutrient, energy, and growth factors. In the last
years, a significant number of pieces have been added to the puzzle of how mTOR
coordinates and executes its functions. Extensive research on mTOR has also uncovered a
complex network of regulatory loops that impact the therapeutic approaches aimed at
targeting mTOR.
The mammalian target of rapamycin (mTOR) is a master regulator of cell growth and division that responds to a variety of stimuli, including nutrient, energy, and growth factors. In the last years, a significant number of pieces have been added to the puzzle of how mTOR coordinates and executes its functions. Extensive research on mTOR has also uncovered a complex network of regulatory loops that impact the therapeutic approaches aimed at targeting mTOR.
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