Populations in developed countries continue to grow older and an understanding of the
ageing process to allow healthy ageing carries important medical implications. Older
individuals are more susceptible to most acquired liver disorders and more vulnerable to the
consequences of liver disease. Accordingly, age is a critical determinant of outcome for
hepatitis C virus infection and liver transplantation. In this review we describe changes in the
ageing liver and discuss mechanisms of senescence at the cellular level. In particular, we …