New anti-HIV aptamers based on tetra-end-linked DNA G-quadruplexes: Effect of the base sequence on anti-HIV activity
Chemical communications, 2012•pubs.rsc.org
This communication reports on the synthesis and biophysical, biological and SAR studies of
a small library of new anti-HIV aptamers based on the tetra-end-linked G-quadruplex
structure. The new aptamers showed EC50 values against HIV-1 in the range of 0.04–0.15
μM as well as affinities for the HIV-1 gp120 envelope in the same order of magnitude.
a small library of new anti-HIV aptamers based on the tetra-end-linked G-quadruplex
structure. The new aptamers showed EC50 values against HIV-1 in the range of 0.04–0.15
μM as well as affinities for the HIV-1 gp120 envelope in the same order of magnitude.
This communication reports on the synthesis and biophysical, biological and SAR studies of a small library of new anti-HIV aptamers based on the tetra-end-linked G-quadruplex structure. The new aptamers showed EC50 values against HIV-1 in the range of 0.04–0.15 μM as well as affinities for the HIV-1 gp120 envelope in the same order of magnitude.
The Royal Society of Chemistry