IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids
C Blanchard, MK Mingler, M Vicario, JP Abonia… - Journal of Allergy and …, 2007 - Elsevier
BACKGROUND: Eosinophilic esophagitis (EE) is an emerging worldwide disease that
mimics gastroesophageal reflux disease. Early studies have established that esophageal
eosinophilia occurs in association with TH2 allergic responses, and we recently identified an
EE-specific esophageal transcriptome that included eotaxin-3. OBJECTIVE: We sought to
determine the mechanism by which this TH2 response leads to EE. METHODS: Real-time
PCR and microarray analysis were performed on RNA extracted from esophageal biopsy …
mimics gastroesophageal reflux disease. Early studies have established that esophageal
eosinophilia occurs in association with TH2 allergic responses, and we recently identified an
EE-specific esophageal transcriptome that included eotaxin-3. OBJECTIVE: We sought to
determine the mechanism by which this TH2 response leads to EE. METHODS: Real-time
PCR and microarray analysis were performed on RNA extracted from esophageal biopsy …