Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1.
ST Smiley, M Reers… - Proceedings of the …, 1991 - National Acad Sciences
Proceedings of the National Academy of Sciences, 1991•National Acad Sciences
By using a potential-dependent J-aggregate-forming delocalized lipophilic cation, 5, 5', 6, 6'-
tetrachloro-1, 1', 3, 3'-tetraethylbenzimidazolocarbocyanine+++ iodide (JC-1), we find that
membrane potentials across mitochondria in a living cell can be heterogeneous.
Remarkably, even within a long contiguous mitochondrion, regional heterogeneity in
membrane potentials appears to be possible.
tetrachloro-1, 1', 3, 3'-tetraethylbenzimidazolocarbocyanine+++ iodide (JC-1), we find that
membrane potentials across mitochondria in a living cell can be heterogeneous.
Remarkably, even within a long contiguous mitochondrion, regional heterogeneity in
membrane potentials appears to be possible.
By using a potential-dependent J-aggregate-forming delocalized lipophilic cation, 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine++ + iodide (JC-1), we find that membrane potentials across mitochondria in a living cell can be heterogeneous. Remarkably, even within a long contiguous mitochondrion, regional heterogeneity in membrane potentials appears to be possible.
National Acad Sciences